Silicified Microcrystalline Cellulose – USP

Solution for Optimum Compatibility

Silicification of MCC increased physical properties such as true density, Hausner ratio, porosity, ejection force and specific surface area. Other properties such as bulk and tap densities were reduced due to the amorphous and light character of fumed silica.

MICCEL S is the mixture of microcrystalline cellulose and colloidal silicon dioxide (MCC/CSD at 98:2 ratio) and most compactible grade of SMC with flow characteristics similar to doubling the parties size of MCC.

Specification

Sr.no. Test Specification
1. Description

 

Solubility

White or almost white, very fine to moderately fine powder. It is a free-flowing material.

Slightly soluble in sodium hydroxide solution (1 in 20); practically insoluble in water, in acetone, in ethanol, in toluene, and in diluted acid.

2. Identification

Test-A (IR Absorption)

Test-B

Test-C

Test-D(silica dispersion uniformity test)

 

Should be comply

The substance takes on a violet-blue color should be produced.

A deep yellow color is produced

NMT 0.02

3 Impurities
3.1 Heavy Metals, µg/g NMT 10
4. Specific Tests
4.1 Residue on Ignition, % 1.8 – 2.2
4.2

4.2.1
4.2.2
4.2.3
4.2.4
4.2.5
4.2.6

Microbiological Analysis

Total Aerobic Microbial Count, CFU/g
Total Combined Molds and Yeasts Count, CFU/g
Escherichia Coli/g
Pseudomonas Aeruginosa/g
Staphylococcus Aureus/ g
Salmonella Species/ 10g

 

NMT 1000
NMT1000
Should be absent
Should be absent
Should be absent
Should be absent

4.3
4.4
4.5
4.6
4.7
4.8
4.9
4.10
Conductivity, µS/cm
pH
Loss on Drying, %
Degree of Polymerization
Bulk Density
Particle Size Distribution
Water Soluble Substances, %
Ether Soluble Substances, %
NMT 75
5.0 – 7.5
NMT 7.0
NMT 350
Refer chart
Refer chart
NMT 0.25
NMT 0.25

 

Grade Wise In House Specification

Test MICCEL S-101 MICCEL S-102 MICCEL S-112
Loss on drying (%) NMT 7.0 NMT 7.0 NMT 1.5
Bulk Density, g/ml 0.28 to 0.33 0.25 to 0.37 0.25 to 0.37
% Retention on 60 # NMT 1 NMT 8 NMT 8
% Retention on 200# NMT 30 NLT 45 NLT 45