USFDA TYPE IV DMF NO. 026433

Microcrystalline Cellulose IP/BP/USP/JP/EP

The MICCEL grades of Microcrystalline Cellulose of Ankit Pulps and Boards, are widely accepted excipients by a number of leading pharmaceutical industries in India for its quality, consistency and customer service. Microcrystalline Cellulose revolutionized tableting because of its unique compressibility and carrying capacity. Its exhibits excellent properties as an excipient for solid dosages forms, compact well under minimum compression pressures, has high binding capability and creates tablets that are extremely hard & stable, yet disintegrate rapidly.

Product

MICCEL 101Wet granulation and direct compressible
MICCEL 102Direct compressible & large particle size
MICCEL 103, MICCEL 112, MICCEL 113Ideal for moisture sensitive material
MICCEL 114Directly compressible
MICCEL 105Enhanced compressibility with combination
MICCEL 200, MICCEL 500, MICCEL 1000Increase flow ability & Direct compressible
MICCEL 301Higher Density, Greater tablet wt.
MICCEL 302Direct compressible, Greater tablet wt.
MICCEL12Direct compressible
MICCEL W, MICCEL WPWet granulation
MICCEL-102 BDHigher density & increase flow

Tablets Manufacturing – Applications

ProcessAdvantagesMethods of use
A. Direct CompressionChemical purity, binder, disintegrant, flow aid, filler, inertnessTable making by direct compression involves only weighing mixing & compressing
B. Wet GranulationBinder, rapid wicking action, permits fast additional of granulation fluid being most absorbent, most inert

Miccel Features

-> Excellent hardness levels at low compression forces

-> Low Lubricant sensitivity

-> Low Tablet Friability

-> Good Disintegration aid

-> Super Stability

Performing in Tablets & Capsules Making

Chemical PurityNon-reactive Organic ingredient, Extremely Low level of organic & Inorganic
Binder High Hardness level, low friability
DisintegrantKeep Uniform Concentration of drug in solution
Flow aidRequire less Lubricant than other typical binders.
InertnessDrug chemical status is maintained.
AbsorbentKeeps drugs uniformly mixed.

Quantum to be used

The amount to be used in direct compression characteristic of the formulation’s other ingredients.

-> Typical use level is of 15 to 20%

-> Granulation use level 15%

-> Levels in excess of 90% has been reported

Co-Processed MCC

Co-processing could lead to formation of excipients with superior quality product compare to the simple physical mixture of their components. Co-processing results in a product with added value related to the ratio of its functionality and price. Development of co-processed directly compressible adjuvant, starts with the selected of the excipients to be combined, their preparation method to get an optimized product with desired physic-chemical parameters.

* We can make custmize excipients according to your requirement.

Grade in house Specification

TestMICCEL 101MICCEL 102MICCEL 103MICCEL 112MICCEL 113MICCEL 114
LOD , %* NMT 7.0/NMT 6.0 * NMT 7.0/NMT 6.0NMT 2.0NMT 1.5NMT 1.5* NMT 7.0/NMT 6.0
BD, g/ml0.22 to 0.340.22 to 0.340.26 to 0.310.28 to 0.380.27 to 0.340.34 to 0.43
+ 60 #, %NMT 1NMT 8NMT 1NMT 8NMT 1NMT 8
+ 200 #, %NMT 30NLT 45NMT 30NLT 45NMT 30NLT 40 and NMT 60

TestMICCEL 1000MICCEL 301MICCEL 302MICCEL 102 BDMICCEL WMICCEL WP
LOD , %* NMT 7.0/ NMT 6.0* NMT 7.0/ NMT 6.0* NMT 7.0/ NMT 6.0* NMT 7.0/ NMT 6.0* NMT 7.0/ NMT 6.0* NMT 7.0/ NMT 6.0
BD, g/ml0.10 to 0.150.34 to 0.510.35 to 0.500.30 to 0.400.25 to 0.350.24 to 0.35
+ 60 #, %NMT 0.5NMT 1NMT 8NMT 8NMT 1NMT 8
+ 200 #, %NMT 20NMT30NLT 45NLT 50NMT 35NMT 35

TestMICCEL 12TestMICCEL 200TestMICCEL 105MICCEL 500
LOD , %* NMT 7.0/NMT 6.0LOD , %* NMT 7.0/NMT 6.0LOD , %* NMT 7.0/NMT 6.0* NMT 7.0/NMT 6.0
BD, g/ml0.25 to 0.37BD, g/ml0.29 to 0.36BD, g/ml0.20 to 0.300.27 to 0.37
+ 40 #, % NMT 1+ 60 #, % NLT 10+ 60 #, % NLT 50
+100 #, %NMT 50+ 100 #, %NLT 50+ 400 #, %NMT 1
+325 #, %NLT 70

LOD :  Loss on drying, BD: Bulk density

Note :  (*) Loss on drying as per IP NMT 6.0 % and as per BP/EP/USP/JP NMT 7.0 %.

-> Low Moisture Grade:  MICCEL 112, MICCEL 113, MICCEL 103.

-> High Bulk Density Grade:  MICCEL 301, MICCEL 302, MICCEL 102 BD.

-> Directly Compressible Grade:  MICCEL 102, MICCEL 102 BD, MICCEL 112, MICCEL 114, MICCEL 200, MICCEL 302.

-> Wet Granulation:  MICCEL 101, MICCEL 105, MICCEL 301, MICCEL W, MICCEL WP.

-> Superior Flow:  MICCEL 200, MICCEL 500.

-> Super Compatibility: MICCEL 105.

Available Packaging Type

TypeSize
HDPE Bags25Kg
Fibreboard Drum25Kg

*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost

ContainerPalletizedNon-Palletized
20 Ft. (Approx Wt.)10,000 Kg11,000 Kg
40 Ft. (Approx Wt.)20,000 Kg25,000 Kg

Unique Features of Microcrystaline Cellulose

  • Angle of Repose
  • Customized Bulk Density
  • Excellent Flowability
  • Better Compressibility

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