USFDA TYPE IV DMF NO. 026433
Microcrystalline Cellulose IP/BP/USP/JP/EP
The MICCEL grades of Microcrystalline Cellulose of Ankit Pulps and Boards, are widely accepted excipients by a number of leading pharmaceutical industries in India for its quality, consistency and customer service. Microcrystalline Cellulose revolutionized tableting because of its unique compressibility and carrying capacity. Its exhibits excellent properties as an excipient for solid dosages forms, compact well under minimum compression pressures, has high binding capability and creates tablets that are extremely hard & stable, yet disintegrate rapidly.
Product
| MICCEL 101 | Wet granulation and direct compressible |
| MICCEL 102 | Direct compressible & large particle size |
| MICCEL 103, MICCEL 112, MICCEL 113 | Ideal for moisture sensitive material |
| MICCEL 114 | Directly compressible |
| MICCEL 105 | Enhanced compressibility with combination |
| MICCEL 200, MICCEL 500, MICCEL 1000 | Increase flow ability & Direct compressible |
| MICCEL 301 | Higher Density, Greater tablet wt. |
| MICCEL 302 | Direct compressible, Greater tablet wt. |
| MICCEL12 | Direct compressible |
| MICCEL W, MICCEL WP | Wet granulation |
| MICCEL-102 BD | Higher density & increase flow |
Tablets Manufacturing – Applications
| Process | Advantages | Methods of use |
|---|---|---|
| A. Direct Compression | Chemical purity, binder, disintegrant, flow aid, filler, inertness | Table making by direct compression involves only weighing mixing & compressing |
| B. Wet Granulation | Binder, rapid wicking action, permits fast additional of granulation fluid being most absorbent, most inert |
Miccel Features
-> Excellent hardness levels at low compression forces
-> Low Lubricant sensitivity
-> Low Tablet Friability
-> Good Disintegration aid
-> Super Stability
Performing in Tablets & Capsules Making
| Chemical Purity | Non-reactive Organic ingredient, Extremely Low level of organic & Inorganic |
| Binder | High Hardness level, low friability |
| Disintegrant | Keep Uniform Concentration of drug in solution |
| Flow aid | Require less Lubricant than other typical binders. |
| Inertness | Drug chemical status is maintained. |
| Absorbent | Keeps drugs uniformly mixed. |
Quantum to be used
The amount to be used in direct compression characteristic of the formulation’s other ingredients.
-> Typical use level is of 15 to 20%
-> Granulation use level 15%
-> Levels in excess of 90% has been reported
Co-Processed MCC
Co-processing could lead to formation of excipients with superior quality product compare to the simple physical mixture of their components. Co-processing results in a product with added value related to the ratio of its functionality and price. Development of co-processed directly compressible adjuvant, starts with the selected of the excipients to be combined, their preparation method to get an optimized product with desired physic-chemical parameters.
* We can make custmize excipients according to your requirement.
Grade in house Specification
| Test | MICCEL 101 | MICCEL 102 | MICCEL 103 | MICCEL 112 | MICCEL 113 | MICCEL 114 |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 | NMT 2.0 | NMT 1.5 | NMT 1.5 | * NMT 7.0/NMT 6.0 |
| BD, g/ml | 0.22 to 0.34 | 0.22 to 0.34 | 0.26 to 0.31 | 0.28 to 0.38 | 0.27 to 0.34 | 0.34 to 0.43 |
| + 60 #, % | NMT 1 | NMT 8 | NMT 1 | NMT 8 | NMT 1 | NMT 8 |
| + 200 #, % | NMT 30 | NLT 45 | NMT 30 | NLT 45 | NMT 30 | NLT 40 and NMT 60 |
| Test | MICCEL 1000 | MICCEL 301 | MICCEL 302 | MICCEL 102 BD | MICCEL W | MICCEL WP |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 |
| BD, g/ml | 0.10 to 0.15 | 0.34 to 0.51 | 0.35 to 0.50 | 0.30 to 0.40 | 0.25 to 0.35 | 0.24 to 0.35 |
| + 60 #, % | NMT 0.5 | NMT 1 | NMT 8 | NMT 8 | NMT 1 | NMT 8 |
| + 200 #, % | NMT 20 | NMT30 | NLT 45 | NLT 50 | NMT 35 | NMT 35 |
| Test | MICCEL 1000 | MICCEL 301 | MICCEL 302 | MICCEL 102 BD | MICCEL W | MICCEL WP |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 | * NMT 7.0/ NMT 6.0 |
| BD, g/ml | 0.10 to 0.15 | 0.34 to 0.51 | 0.35 to 0.50 | 0.30 to 0.40 | 0.25 to 0.35 | 0.24 to 0.35 |
| + 60 #, % | NMT 0.5 | NMT 1 | NMT 8 | NMT 8 | NMT 1 | NMT 8 |
| + 200 #, % | NMT 20 | NMT30 | NLT 45 | NLT 50 | NMT 35 | NMT 35 |
| Test | MICCEL 12 | Test | MICCEL 200 | Test | MICCEL 105 | MICCEL 500 |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/NMT 6.0 | LOD , % | * NMT 7.0/NMT 6.0 | LOD , % | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 |
| BD, g/ml | 0.25 to 0.37 | BD, g/ml | 0.29 to 0.36 | BD, g/ml | 0.20 to 0.30 | 0.27 to 0.37 |
| + 40 #, % | NMT 1 | + 60 #, % | NLT 10 | + 60 #, % | NLT 50 | |
| +100 #, % | NMT 50 | + 100 #, % | NLT 50 | + 400 #, % | NMT 1 | |
| +325 #, % | NLT 70 |
LOD : Loss on drying, BD: Bulk density
Note : (*) Loss on drying as per IP NMT 6.0 % and as per BP/EP/USP/JP NMT 7.0 %.
-> Low Moisture Grade: MICCEL 112, MICCEL 113, MICCEL 103.
-> High Bulk Density Grade: MICCEL 301, MICCEL 302, MICCEL 102 BD.
-> Directly Compressible Grade: MICCEL 102, MICCEL 102 BD, MICCEL 112, MICCEL 114, MICCEL 200, MICCEL 302.
-> Wet Granulation: MICCEL 101, MICCEL 105, MICCEL 301, MICCEL W, MICCEL WP.
-> Superior Flow: MICCEL 200, MICCEL 500.
-> Super Compatibility: MICCEL 105.
Packaging Details
Available Packaging Type
| Type | Size |
|---|---|
| HDPE Bags | 25Kg |
| Fibreboard Drum | 25Kg |
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
| Container | Palletized | Non-Palletized |
|---|---|---|
| 20 Ft. (Approx Wt.) | 10,000 Kg | 11,000 Kg |
| 40 Ft. (Approx Wt.) | 20,000 Kg | 25,000 Kg |
Unique Features of Microcrystalline Cellulose
Customized Bulk Density
Excellent Flowability
Better Compressibility
